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Effect of indomethacin-loaded nanocapsules (IndOH-NC) (1 mg·kg−1 IndOH-NC i.p., 14 days after induction of paw oedema, twice a day, for 8 days) on (A) TNF-α and (B) IL-6 and IL-10 levels in serum of animals in the arthritis model. Each point represents the mean of 5–8 animals and vertical lines show the SEM. Significantly different from the control, unloaded nanocapsules (NC) and indomethacin in solution (IndOH) groups for *P < 0.05, **P < 0.01 and ***P < 0.001.
