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. 2009 Sep 28;158(4):1153–1164. doi: 10.1111/j.1476-5381.2009.00383.x

Figure 1.

Figure 1

Cytotoxic effect of nilotinib, dasatinib and bosutinib in parental K562, K562/ABCB1 and K562/ABCG2 cells. Parental K562, K562/ABCB1 and K562/ABCG2 cells were incubated with increasing concentration of nilotinib (A), dasatinib (B) or bosutinib (C) in the presence or in the absence of the specific multidrug resistance ATP-binding cassette inhibitors 1 µM PSC-833 or 5 µM fumitremorgin C (FTC) for 48 h. Cells were then harvested, stained with TOPRO-3 and counted by flow cytometry. The number of living cells relative to those measured in vehicle-treated control samples was plotted against the log of tyrosine kinase inhibitor (TKI) concentrations, and exponential fit was applied. Data represent the mean of at least three independent experiments each in duplicate; bars represent SD.