Receiver operating characteristic curves of NTproBNP and BNP for detecting an ejection fraction of ≤40% in a random sample of the general population ≥45 years of Olmsted County, MN, USA. (A) for the entire population, (B) for patients ≥65 years, (C) for male subjects, and (D) for female subjects. AUC, area under the curve, EF, ejection fraction. From Costello-Boerrigter LC, Boerrigter G, Redfield MM, et al: Amino-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide in the general community: determinants and detection of left ventricular dysfunction. J Am Coll Cardiol 2006;47(2):349, with permission.