FIGURE 1.

Growth of wild type and V- and C-mutant measles virus in ADAR1-deficient and ADAR1-sufficient cells. ADAR1⁺, ADAR1^kd, and CON^kd HeLa cells were infected with WT, V^ko, or C^ko recombinant virus at a multiplicity of infection of 5 TCID₅₀/cell for 36 h. A, fluorescence images showing GFP signal in cells taken immediately before harvest. UI, uninfected cells. B, virus yields from ADAR1-sufficient (parental ADAR1⁺ and CON^kd) and stably ADAR1-deficient (ADAR1^kd) cells were determined by 50% TCID₅₀ titration on Vero cells. The results shown are the means with S.D. (n = 4). *, p < 0.05 by Student's t test for comparison of V^ko and C^ko virus yields in ADAR1^kd cells versus ADAR1-sufficient controls.