TABLE 1.
Anti-influenza activity of thiazolides
A, schematic structure of thiazolides. B, evaluation of the anti-influenza activity of the novel thiazolides RM4803, RM4832, RM4850, RM4865, and RM5014 as compared to NTZ and TIZ. Mock-infected or PR8-infected MDCK cells were treated with different concentrations (0.01, 0.1, 1, 10, and 50 μg/ml) of the compounds immediately after the virus adsorption period. Cell viability and virus yield were determined at 24 h p.i. by MTT assay and hemagglutination assay, respectively. The data, expressed as EC50 and CC50, represent the means ± SD of triplicate experiments. The lack of SD in the CC50 column indicates that the values were identical.
