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CP55,940-mediated inhibition of β−arrestin2 redistribution to GPR55
Log IC50 ± S.E. values were determined from concentration-effect curves. KI values were determined from IC50 values as described under “Experimental Procedures.”
| Competitive agonist | Log IC50 ± S.E. | IC50 | Calculated KI |
|---|---|---|---|
| m | nm | nm | |
| LPI | −6.17 ± 0.17 | 678 | 194 |
| LPI (On-Cell)a | −5.92 ± 0.15 | 1210 | 173 |
| SR141716A | −5.73 ± 0.15 | 1850 | 213 |
| AM251 | −5.56 ± 0.42 | 2750 | 542 |
Inhibition of LPI-mediated receptor internalization.
