FIGURE 2.

Architecture of the dicarboxylate-binding site and ligand in the carboxin-inhibited structure. The stereo figure shows residues within 4.0 Å of the ligand TEO, a malate-like intermediate. Interactions between residues and the ligand are shown as red dotted lines. The density, shown as a blue mesh, is a 2mF_o − DF_c map, contoured at 1.8 σ. Residues 251–253 and 354 of SdhA have been removed to enable a clearer view of the binding site.