TABLE 1.

Sensitivity of mammalian cells to FA and azadC

Cell	Mutation	Defect	Sensitivitya
			FA	azadC
CHO cells
AA8	WT	None	Control	Control
51D1	RAD51D	HR	++	++
51D1.3	RAD51 + cDNAb	HR corrected	−	−
irs1SF	XRCC3	HR	+++	+++
V3	DNA-PKcs	NHEJ	−	−
UV5	ERCC2 (XPD)	NER	+	−c
UV41	ERCC4 (XPF)	NER	++	+d
Human cells
WI38VA13	WT	None	Control	Control
XP12ROSV	XPA	NER	+	−
XP2OSSV	XPA	NER	+	−
XP6BESV	XPD	NER	+	−

^a Symbols denote sensitivity relative to WT cells for 0.3 mm FA or 2 μm azadC as follows: no sensitivity (−) and sensitivity increased by 1 order (+), 2 orders (++), and 3 orders (+++) of magnitude. Data were from survival curves in Fig. 2E for human cells and in supplemental Fig. S5 for CHO cells. Survival curves for V3 and XP6BESV cells are not shown.

^b Complemented with hamster RAD51D cDNA.

^c Slightly resistant (2.3-fold) relative to WT cells.

^d Slightly sensitive (2.8-fold) relative to WT cells.