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Syndecan-2-mediated cell migration is independent of melanin synthesis. A, after B16F10 cells were treated with either α-MSH (1.0 μm) or kojic acid (200 μM) for 48 h, the melanin content of the cells was measured as described under “Experimental Procedures.” Cell surface expression of syndecan-2 (B) and cell migration activity (C) were analyzed as described in the legend to Fig. 3. Columns, average of three independent experiments. *, p < 0.05; **, p < 0.01 versus control.
