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. 2009 Aug 7;284(40):27273–27280. doi: 10.1074/jbc.M109.014464

FIGURE 4.

FIGURE 4.

UPR components were up-regulated in 3-month-old adult Arg-61 apoE astrocytes. A–D, OASIS (A and B), ATF4 (C), and XBP-1 (D), mRNA levels were notably increased in Arg-61 apoE astrocytes. In Apoe+/− astrocytes, which had 50% lower apoE levels than WT astrocytes, UPR components were not up-regulated (n = 8 WT, n = 6 Arg-61 apoE, and n = 7 Apoe+/− mice; *, p < 0.05 versus WT for OASIS, XBP-1, and ATF4; *, p > 0.05 versus WT). D, the mRNA levels of OASIS were markedly elevated with ∼70% more than Arg-61 apoE neonatal astrocytes (*, p < 0.01).