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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Sep 9;19(21):6122–6126. doi: 10.1016/j.bmcl.2009.09.010

Scheme 3.

Scheme 3

(Method C). (a) mesitylSO3NH2, DCM, 0 °C to rt, 30 min, 81%; (b) HC≡CCO2Me, K2CO3, DMF, 50 °C, 72 h, 14%; (c) LiOH, MeOH/H2O, rt, 2 h, then 1N HCl, 85–90%; (d) SOCl2, 80 °C, 1 h; (e) 2-ClPhNH2, pyridine, rt, 16 h.