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. 2009 Nov 18;5:67. doi: 10.1186/1744-8069-5-67

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Copyright ©2009 Kim et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Attenuation of neuropathic pain behavior upon post-injection with rAAV-shGCH1. Pain hypersensitivity of the rats was measured using up-and-down methods with the von Frey filaments on the designated days. Values below the broken line (threshold = 4) represent pain-like behavior. Data are presented as means ± SEM (n = 10 for rAAV-shGCH1 and rAAV-GFP- injected pain groups; n = 6 for the normal control group). An asterisk (*) indicates that the rAAV-shGCH1-injected group significantly differs from the rAAV-GFP-injected group (*p < 0.05). black square, rAAV-GFP; open square, rAAV-shGCH1.