Table 1.

Incidence of pleural effusion in patients with CP CML with exposure to dasatinib

	Dosage
	70 mg twice daily n = 167	100 mg once daily n = 166	P-value
Pleural effusiona
All grades	26 (16%)	12 (7%)	0.024
Grades 3-4	2 (1%)	2 (1%)	-

^aClassifications are as follows: grade 1, asymptomatic; grade 2, symptomatic, intervention with diuretics or up to two therapeutic thoracenteses indicated; grade 3, symptomatic and supplemental oxygen is required, greater than two therapeutic thoracenteses, tube drainage, or pleurodesis indicated; grade 4, life-threatening (e.g., causing hemodynamic instability); grade 5, death.

Data from Shah et al[22]