Figure 9.
Nuclear levels of p53 in wild-type and Δtrr1 yeast transformants. Equal amounts of nuclear protein (20 µg) from triplicate samples of wild-type (TRR1) and mutant (Δtrr1) yeast transformed with wild-type p53 allele were resolved by SDS-PAGE, and p53 and histone H2A were detected by immunoblotting. Numbers below each set of lanes show densitometric intensity of p53 bands normalized to histone H2A bands (mean ± S.D.), with wild-type results arbitrarily set at 100 and Δtrr1 ratio normalized accordingly.