Table 2.
Association between stress reactivity measures and eGFR <60 ml/min/1.73 m2
| Hemodynamic measure | Unadjusted | Model 1 | Model 2 | Model3 | Test for task–eGFR interaction |
|---|---|---|---|---|---|
| ΔSBP | 8.5 (2.4, 14.6) | 7.8 (2.0, 13.6) | 8.0 (2.3, 13.6) | 7.0 (0.6, 13.4) | 0.6 |
| p = 0.005 | p = 0.009 | p = 0.007 | p = 0.03 | ||
| ΔDBP | 3.3 (−0.8, 7.5) | 2.2 (−1.5, 5.9) | 2.4 (−1.4, 6.2) | 1.8 (−2.0, 5.7) | 0.9 |
| p = 0.12 | p = 0.2 | p = 0.2 | p = 0.3 | ||
| ΔHeart rate | 2.5 (−0.8, 5.9) | 3.3 (0.1, 6.4) | 3.6 (0.3, 6.8) | 3.1 (−0.8, 6.2) | 0.3 |
| p = 0.14 | p = 0.04 | p = 0.03 | p = 0.056 | ||
| ΔPulse pressure | 5.7 (1.5, 9.9) | 5.9 (1.8, 9.9) | 5.8 (1.7, 10.0) | 5.5 (1.0, 10.0) | 0.5 |
| p = 0.008 | p = 0.004 | p = 0.006 | p = 0.018 |
Regression coefficients represent the adjusted average difference in stress reactivity between those with an eGFR of <60 ml/min/1.73 m2 or ≥60 ml/min/1.73 m2. Stress reactivity measures were computed for all 3 stressors.
Model 1: adjusted for age, gender, race, body mass index (kg/m2), aspirin use, and hypertension.
Model 2: additionally adjusted for fasting glucose and plasma glucose 120 min following an oral glucose load. Model 3: Adjusted for covariates in model 1 and additionally for HDL-C, triglycerides, and LDL-C.