Table 3.
Association between eGFR and stress reactivity measures
| Hemodynamic measure | Regression coefficient (95% CI) |
Test for task–GFR interaction | |||
|---|---|---|---|---|---|
| unadjusted | model 1 | model 2 | model 3 | ||
| ΔSBP | 1.32 (0.29, 2.36) | 0.99 (−0.09, 2.08) | 1.35 (0.29, 2.41) | 0.85 (−0.20, 1.90) | 0.7 |
| ΔDBP | 0.70 (0.11, 1.28) | 0.47 (−0.12, 1.07) | 0.68 (0.11, 1.25) | 0.44 (−0.16, 1.03) | 0.8 |
| ΔHeart rate | 0.17 (−0.37, 0.72) | 0.06 (−0.50, 0.61) | 0.25 (−0.29, 0.79) | −0.03 (−0.59, 0.52) | 0.4 |
| ΔPulse pressure | 0.71 (−0.02, 1.45) | 0.58 (−0.19, 1.36) | 0.74 (−0.04, 1.52) | 0.47 (−0.27, 1.20) | 0.7 |
Regression coefficients represent the difference in mean stress response associated with a 10 ml/min lower eGFR, holding other factors constant. Stress reactivity measures were computed for all 3 stressors combined.
Model 1: Adjusted for age, gender, race, sex, body mass index (kg/m2), aspirin use, and hypertension.
Model 2: Additionally adjusted for fasting glucose and plasma glucose 120 min following oral glucose load. Model
3: Adjusted for covariates in model 1 and additionally for HDL-C, triglycerides, and LDL-C.