Table 1.
Demographics, clinicopathologic tumour characteristics and treatments for the patients in the Duke University Medical Center (DUMC) and Memorial-Sloan Kettering Cancer Center (MSKCC) cohorts are compared. Continuous variables are listed as medians with 1st and 3rd quartiles, discrete variables are listed with percentages
| Variables | MSKCC | DUMC | P |
|---|---|---|---|
| n | 1475 | 203 | – |
| Gender | 0.770 | ||
| Male | 853 (57.8%) | 120 (59.1%) | |
| Female | 624 (42.2%) | 83 (40.9%) | |
| Primary tumour | 0.281 | ||
| Colon | 1092 (74.0%) | 158 (77.8%) | |
| Rectum | 383 (26.0%) | 45 (22.2%) | |
| Primary lymph node | 0.1373 | ||
| 0 | 564 (40.1%) | 66 (34.7%) | |
| 1 | 588 (41.8%) | 79 (41.6%) | |
| 2 | 255 (18.1%) | 45 (23.7%) | |
| Pre-operative CEA (ng/ml) | 16.4 (5.7, 64.3) | 8.9 (2.9, 30.1) | <0.0001 |
| Number of CRLM | 2 (1, 3) | 1 (1, 2) | 0.0016 |
| Size of largest CRLM (cm) | 4.1 (2.8, 6.4) | 3.4 (2.2, 5.5) | 0.0002 |
| Age (year) | 62.8 (54.2, 69.6) | 61.0 (51.8, 68.8) | 0.06 |
| Disease-free interval (mo) | 14.4 (4.4,26) | 2 (0, 16) | <0.0001 |
| Bilateral resection | |||
| No | 890 (60.3%) | 150 (73.9%) | 0.0002 |
| Yes | 587 (39.7%) | 53 (26.1%) | |
| >1 Lobe resected | |||
| No | 528 (35.7%) | 133 (65.5%) | <0.0001 |
| Yes | 949 (64.3%) | 70 (34.5%) |
CRLM, colorectal liver metastases; CEA, carcino-embyronic antigen.
Disease-free interval refers to interval from resection of the primary tumour to diagnosis of CRLM.