Table 3.

Odds ratios (95% confidence intervals) of case status (worsening kidney function) by baseline levels and changes over time of biomarkers

Risk factors (per SD)	Unadjusted OR (95% CI)	p	Adjusted1OR (95% CI)	p	Adjusted2OR (95% CI)	p
Baseline
CRP, mg/l (11.5)	1.89 (1.30–2.75)	0.001	1.73 (1.20–2.51)	0.004	−
IL-6, pg/ml (1.6)	1.30 (1.04–1.62)	0.02	1.16 (0.93–1.44)	0.19	−
Fibrinogen, mg/dl (70.2)	1.31 (1.07–1.60)	0.01	1.22 (0.99–1.50)	0.07	−
Factor VII, % (31.7)	1.19 (0.97–1.45)	0.09	1.19 (0.97–1.46)	0.10	−
Factor VIII, % (40.9)	1.17 (0.96–1.43)	0.11	1.11 (0.91–1.37)	0.30	−
HDL, mg/dl (15.3)	0.81 (0.67–0.99)	0.04	0.89 (0.72–1.10)	0.27	−
LDL, mg/dl (36.4)	0.93 (0.76–1.13)	0.46	0.90 (0.74–1.11)	0.32	−
Triglycerides, mg/dl (88.6)	1.26 (1.02–1.56)	0.03	1.17 (0.94–1.45)	0.17	−
Change
CRP, mg/l (15.4)	0.96 (0.79–1.17)	0.68	0.94 (0.77–1.15)	0.56	1.18 (0.86–1.60)	0.30
IL-6, pg/ml (2.9)	1.28 (1.04–1.59)	0.02	1.19 (0.95–1.49)	0.12	1.22 (0.98–1.53)	0.08
Fibrinogen, mg/dl (72.7)	1.21 (0.99–1.47)	0.07	1.17 (0.95–1.43)	0.14	1.38 (1.08–1.76)	0.01
Factor VII, % (24.3)	0.99 (0.82–1.21)	0.94	1.03 (0.84–1.27)	0.77	1.14 (0.90–1.44)	0.27
Factor VIII, % (50.3)	1.38 (1.11–1.71)	0.003	1.36 (1.09–1.70)	0.006	1.38 (1.10–1.72)	0.005
HDL, mg/dl (7.6)	0.90 (0.74–1.10)	0.30	0.87 (0.71–1.07)	0.18	0.80 (0.64–1.00)	0.05
LDL, mg/dl (26.6)	1.00 (0.82–1.22)	0.99	1.05 (0.85–1.29)	0.64	1.02 (0.82–1.27)	0.87
Triglycerides, mg/dl (79.7)	1.17 (0.93–1.47)	0.12	1.19 (0.92–1.53)	0.09	1.21 (0.93–1.57)	0.01

¹Adjusted for systolic blood pressure, diuretics, prevalent CVD, internal carotid IMT.

²Adjusted for systolic blood pressure, diuretics, prevalent CVD, internal carotid IMT and baseline measure.