Table 1.
Descriptive characteristics by NT-proBNP category
| NT-proBNP category ∗ |
||||||
|---|---|---|---|---|---|---|
| overall | undetectable | low | moderate | high | p trend | |
| Number | 970 | 200 | 355 | 207 | 208 | |
| NT-proBNP, median (IQR), pg/ml | 153 (63, 442) | − | 110 (77, 161) | 308 (228, 413) | 1,094 (677, 2,025) | <0.001 |
| Glomerular filtration rate, ml/min/1.73 m2 | 46.5 ± 13.6 | 54.2 ± 11.3 | 47.8 ± 12.6 | 44.4 ± 14.3 | 39.0 ± 12.4 | <0.001 |
| Hematocrit, % | 39.4 ± 4.9 | 41.0 ± 4.8 | 39.3 ± 4.4 | 39.0 ± 5.0 | 38.2 ± 5.4 | <0.001 |
| BMI | 30.7 ± 6.6 | 31.6 ± 6.3 | 30.5 ± 6.3 | 30.6 ± 6.9 | 30.5 ± 7.1 | 0.13 |
| Systolic blood pressure, mm Hg | 150.2 ± 24.0 | 141.3 ± 20.0 | 147.7 ± 23.0 | 150.6 ± 23.2 | 162.8 ± 24.9 | <0.001 |
| Protein:creatinine ratio, median (IQR) | 0.08 (0.03, 0.37) | 0.03 (0.02, 0.09) | 0.06 (0.03, 0.23) | 0.12 (0.04, 0.56) | 0.24 (0.08, 0.70) | <0.001 |
| Proteinuria (Pr:Cr >0.22), n (%) | 319 (33.0) | 34 (10.7) | 92 (29.0) | 83 (26.0) | 110 (34.6) | <0.001 |
| C-reactive protein, mg/l | 0.8 ± 1.0 | 0.7 ± 0.8 | 0.8 ± 1.1 | 0.8 ± 1.1 | 0.8 ± 1.0 | 0.27 |
| Age, years | 54.6 ± 10.6 | 53.4 ± 10.6 | 58.2 ± 8.8 | 51.8 ± 11.0 | 52.3 ± 11.3 | <0.001 |
| Female, n (%) | 378 (39.0) | 66 (17.5) | 160 (42.3) | 75 (19.8) | 77 (20.4) | 0.91 |
| History of heart disease, n (%) | 504 (52.0) | 51 (13.8) | 102 (27.5) | 93 (25.1) | 125 (33.7) | <0.001 |
| Cholesterol, mg/dl | ||||||
| HDL | 48.2 ± 16.1 | 45.4 ± 14.9 | 49.1 ± 16.7 | 48.3 ± 16.1 | 49.5 ± 16.1 | 0.04 |
| Non-HDL | 163.4 ± 44.9 | 176.0 ± 41.9 | 163.7 ± 40.4 | 158.5 ± 48.3 | 156.0 ± 49.0 | <0.001 |
| Duration of hypertension, years | 14.2 ± 10.0 | 12.5 ± 9.5 | 15.8 ± 10.4 | 13.3 ± 9.7 | 14.3 ± 10.0 | 0.64 |
| LVH by EKG, n (%) | 371 (38.3) | 51 (13.6) | 102 (27.3) | 95 (25.4) | 126 (33.7) | <0.001 |
Low – for <50 years of age: men: 50–88 pg/ml, women: 50–153 pg/ml; for ≥50 years of age: men: 50–227 pg/ml, women: 50–334 pg/ml.
Moderate – for <50 years of age: men: 88–472 pg/ml, women: 153–565 pg/ml; for ≥50 years of age: men: 227–472 pg/ml, women: 334–565 pg/ml.
High – men: ≥472 pg/ml, women: ≥562 pg/ml.
IQR = Interquartile range.
∗
NT-proBNP categories: Undetectable <50 pg/ml.