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. Author manuscript; available in PMC: 2010 Nov 25.
Published in final edited form as: Tetrahedron Lett. 2009 Nov 25;50(47):6494–9497. doi: 10.1016/j.tetlet.2009.09.024

Table 1.

Yields (%) and purity (%) of substituted quinolones 7(1-72) produced via Scheme 1.

Entry/
R1 =		 R2 =
H		 R2 =
Me		 R2 =
Ph		 R2 =
4-(Me)C6H4 		R2 =
4-(C5H11)C6H4 		R2 =
4-(MeO)C6H4 		R2 =
3-FC6H4 		R2 =
2,4-(F)2C6H3
H 43 / >95 14 / >95 12 / >95 34 / 95 7 / >95 59 / 95 67 / >95 67 / 94
7-Cl 64 / >95 36 / >95 81 / >95 95 / >95 7 / >95 30 / 80 69 / >95 23 / 85
6-Cl 79 / >95 40 / >95 88 / >95 63 / >95 17 / >95 35 / >95 73 / 95 25 / 95
6-F 74 / >95 18 / >95 63 / >95 86 / >95 9 / 85 90 / >95 20 / >95 91 / 95
6-Me 78 / >95 15 / >95 35 / >95 67 / >95 3 / >95 60 / >95 81 / >95 32 / >95
6-MeO 38 / >95 Trace/n.a. 14 / >95 68 / >95 8 / >95 65 / >95 77 / >95 87 / >95
6,7-MeO)2 72 / >95 8 / >95 5 / >95 88 / >95 6 / 95 52 / >95 92 / >95 36 / >95
7-F 11 / >95 19 / >95 66 / 95 74 / >95 9 / 95 83 / >95 93 / >95 31 / 95
5-F 86 / 90 Trace/n.a. 39 / 95 57 / >95 34 / >95 31 / >95 68 / 90 Trace/n.a.
a

Table entries are yields%/purity%.8