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. Author manuscript; available in PMC: 2010 Jan 16.
Published in final edited form as: Nature. 2009 Jul 8;460(7253):392–395. doi: 10.1038/nature08221

Table 1. The effect of rapamycin on maximum lifespan.

Comparison Sites Age at 90th Percentile for Controls (UL*) Age at 90th Percentile for Rapa Percent Increase
Females, Rapa vs Control All sites 1094 (1136) 1245 14%
Females, Rapa vs Control TJL 1100 (1165) 1282 17%
Females, Rapa vs Control UM 1094 (1149) 1250 14%
Females, Rapa vs Control UT 1089 (1159) 1179 8%
Males, Rapa vs Control All sites 1078 (1111) 1179 9%
Males, Rapa vs Control TJL 1035 (1091) 1142 10%
Males, Rapa vs Control UM 1141 (1177) 1188 4%
Males, Rapa vs Control UT 1020 (1101) 1179 16%
*

Note: “UL” = upper limit of the 95% confidence interval for control mice. For example, top row, for females pooled across sites, the 95% confidence interval for controls goes up to 1136 days, and the estimate for 90th percentile survival for the rapamycin-treated mice is 1245 days. This gives good evidence that the 90th percentile survival for Rapa (1245) is substantially above that for Controls (1094).