Table 4.

Association of Change in BDI to Change in Relative Brain Activity

Cluster-level						Peak Voxel
Positive Covariation (Both measures decrease or increase in parallel)
		Volume corrected Spatial Extent p Value	Max. Cluster Size (voxels)	p<.01 voxels in Total ROI	% ROI	Volume corrected Voxel Height p Value	Z- Score	Coordinates (x, y, z)
Parietal Lobe	Left	.364	18	18	1%	.289	2.65	−28	−32	68
	Right	.045	432	432	17%	.029	3.66	38	−32	68
Amygdala	Left
	Right	.048	3	3	9%	.036	2.50	28	−4	−16
Dorsal Striatum	Left	.079	176	176	16%	.012	3.69	−20	16	−6
	Right	.078	192	192	21%	.003	4.11	22	16	−6
Ventral Striatum	Left	.031	85	85	57%	.002	3.72	−20	14	−8
	Right	.042	56	56	33%	<.0005*	4.43	20	14	−10

Negative Covariation (One measure increases when the other decreases)
Lateral Orbitofrontal	Left	.171	89	89	5%	.082	3.13	−34	40	−6
	Right	.099	242	242	13%	.008	3.92	52	22	−8
Medial Orbitofrontal	Left	.195	32	37	3%	.126	2.81	−18	44	−24
	Right	.048	260	269	21%	.099	2.92	16	52	−18
Insula	Left	.064	219	220	16%	.003	4.11	−34	8	16
	Right	.041	298	298	22%	.010	3.77	36	−8	16
ACCsg	Left	.128	68	68	7%	.055	3.07	−2	60	14
	Right	.043	272	272	27%	.048	3.15	12	38	−4
ACCig	Left	.094	7	7	3%	.077	2.51	−2	20	−14
	Right	.032	126	126	56%	.014	3.17	12	38	−6
Dorsal Striatum	Left	.093	147	163	15%	.041	3.27	−18	16	14
	Right	.175	61	80	9%	.033	3.38	30	−2	12

^*Statistical significance maintained after applying the Bonferroni correction for 40 comparisons (.05 / 40 = .0012).