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. Author manuscript; available in PMC: 2010 Nov 12.
Published in final edited form as: J Med Chem. 2009 Nov 12;52(21):6649–6659. doi: 10.1021/jm9008899

Table 3.

Experimental activities of PTPN1 inhibitors across different classical PTPs.

Molecule PTPN2 PTPN1 PTPRC PTPRF PTPN6 PTPRB PTPRE PTPRA
graphic file with name nihms151484t6.jpg a1 1.3 3.2 280 >500 - - - -
graphic file with name nihms151484t7.jpg a2 0.026 0.036 151 >1000 - - - -
graphic file with name nihms151484t8.jpg b1 1 1.6 64 >1000 - - - -
graphic file with name nihms151484t9.jpg b2 0.68 0.82 55 320 - - - -
graphic file with name nihms151484t10.jpg b3 0.32 0.3 26 >1000 - - - -
graphic file with name nihms151484t11.jpg b4 0.18 0.14 33 >1000 - - - -
graphic file with name nihms151484t12.jpg c1 4.1 9.2 >1250 1100 - - - -
graphic file with name nihms151484t13.jpg d1 - 23 160 >2000 510 33 130 870
graphic file with name nihms151484t14.jpg d2 - 9.9 37 68 94 14 45 190
graphic file with name nihms151484t15.jpg d3 - 14 56 550 16 6 66 800
graphic file with name nihms151484t16.jpg d4 - 8 20 450 28 3.6 33 180
graphic file with name nihms151484t17.jpg d5 - 14 49 420 84 17 33 89
graphic file with name nihms151484t18.jpg e1 - 58 260 >2000 >2000 160 360 >2000
graphic file with name nihms151484t19.jpg e2 - 62 210 >2000 60 18 740 1700
graphic file with name nihms151484t20.jpg e3 - 8.1 41 410 100 19 45 290
graphic file with name nihms151484t21.jpg e4 - 0.29 59 >2000 >2000 560 1100 >2000
graphic file with name nihms151484t22.jpg e5 - 14 53 360 350 11 20 170
graphic file with name nihms151484t23.jpg f1 1.1 0.6 489 176 289 21 >500 >500

Activity given as inhibition constant Ki in µM.