Table 2.
Multivariable-adjusted* odds ratios (OR) and 95% confidence intervals (CI) between selected polymorphisms in genes in the one-carbon metabolism pathway and ovarian cancer risk among 1,770 Caucasian subjects, Mayo Clinic, MN and Duke University, NC, 1999–2006
| Homozygotes common allele (Referent) | Heterozygotes | Homozygotes rarer allele | Ordinal (Per rare allele) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene/SNP rsID | Cases | Controls | Cases | Controls | OR (95% CI) | Cases | Controls | OR (95% CI) | 2df P | OR (95% CI) | P trend |
| AHCYL1 | |||||||||||
| 17668350 | 684 | 806 | 141 | 127 | 1.4 (1.0–1.8) | 3 | 8 | 0.4 (0.1–1.7) | 0.04 | 1.2 (0.9–1.6) | 0.11 |
| DNMT3A | |||||||||||
| 13420827 | 552 | 602 | 234 | 308 | 0.8 (0.7–1.0) | 38 | 28 | 1.5 (0.9–2.6) | 0.03 | 1.0 (0.8–1.1) | 0.68 |
| DPYD | |||||||||||
| 1801265 | 463 | 585 | 321 | 318 | 1.3 (1.0–1.6) | 44 | 38 | 1.4 (0.9–2.2) | 0.04 | 1.2 (1.0–1.5) | 0.01 |
| MTHFD1 | |||||||||||
| 1950902 | 552 | 586 | 250 | 306 | 0.9 (0.7–1.1) | 17 | 37 | 0.5 (0.3–0.9) | 0.06 | 0.8 (0.7–1.0) | 0.04 |
| 2236225 | 229 | 288 | 421 | 481 | 1.1 (0.9–1.4) | 174 | 166 | 1.3 (1.0–1.8) | 0.15 | 1.1 (1.0–1.3) | 0.05 |
| 11849530 | 508 | 512 | 273 | 375 | 0.7 (0.6–0.9) | 48 | 53 | 0.9 (0.6–1.3) | 0.02 | 0.8 (0.7–1.0) | 0.03 |
| MTHFS | |||||||||||
| 17284990 | 502 | 557 | 262 | 338 | 0.9 (0.7–1.1) | 64 | 45 | 1.6 (1.1–2.5) | 0.01 | 1.1 (0.9–1.2) | 0.49 |
| SHMT1 | |||||||||||
| 9909104 | 437 | 539 | 317 | 340 | 1.2 (0.9–1.4) | 73 | 61 | 1.5 (1.0–2.2) | 0.09 | 1.2 (1.0–1.4) | 0.02 |
| SLC19A1 | |||||||||||
| 3788205 | 422 | 434 | 331 | 409 | 0.8 (0.7–1.0) | 75 | 98 | 0.8 (0.5–1.1) | 0.10 | 0.9 (0.7–1.0) | 0.04 |
| TYMS | |||||||||||
| 495139 | 282 | 352 | 390 | 449 | 1.1 (0.8–1.3) | 154 | 140 | 1.4 (1.0–1.8) | 0.10 | 1.1 (1.0–1.3) | 0.05 |
*
Adjusted for age (<40, 40–49, 50–59, 60–69, 70+), state (MN, IA, WI, IL, ND/SD, NC), BMI in kg/m2 (<23, 23–25.9, 26–28.9, 29+), postmenopausal hormone use (never, 1–60 months, 60+ months), oral contraceptive use (never, 1–48 months, 48+ months) and parity/age at first birth (nulliparous, 1–2/≤20 y, 1–2/>20 y, 3+/≤20 y, 3+/>20 y).