Table 4.

Age and residence-adjusted odds ratios (OR) and 95% confidence intervals (CI) for the joint effect of selected polymorphisms in genes in the one-carbon metabolism pathway and multivitamin supplement use using an ordinal model for ovarian cancer risk among 1,770 Caucasian subjects, Mayo Clinic, MN and Duke University, NC, 1999–2006

	Multivitamin Non Users				Multivitamin Users
	Homozygous common allele (Referent)	Heterozygous	Homozygous rare allele	Ordinal (Per rare allele)	Homozygous common allele (Referent)	Heterozygous	Homozygous rare allele	Ordinal (Per rare allele)
Gene/SNP rsID	Cases/Controls	Cases/Controls	Cases/Controls	OR (95% CI)	Cases/Controls	Cases/Controls	Cases/Controls	OR (95% CI)	P inter-action
DNMT3A
11887120	93/149	142/175	70/64	1.3 (1.0–1.6)	124/157	151/264	58/88	0.8 (0.7–1.0)	0.007
11695471	154/165	123/163	30/58	0.8 (0.6–1.0)	126/224	170/234	39/51	1.2 (1.0–1.5)	0.01
13420827	192/252	95/129	19/6	1.3 (1.0–1.7)	237/321	84/166	13/20	0.8 (0.6–1.0)	0.006
DNMT1
9305012	268/345	36/42	4/1	1.3 (0.9–2.1)	306/442	30/65	0/2	0.6 (0.4–1.0)	0.03
MTHFR
2184226	252/337	53/48	2/3	1.3 (0.9–1.9)	418/288	44/80	3/9	0.7 (0.5–1.1)	0.05
MTHFD1
17101854	296/367	13/21	0	0.6 (0.3–1.3)	311/488	25/21	0	2.0 (1.0–3.7)	0.02