TABLE 2.
Characteristics of the 54 adult patients with TDM of PSZ
| Characteristic | Value for patients receiving: |
Value for all patients (n = 54) | |||||
|---|---|---|---|---|---|---|---|
| Prophylaxis (n = 36) |
Curative treatment (n = 18) |
||||||
| PPC, <500 ng/ml | PPC, ≥500 ng/ml | P | PPC, <500 ng/ml | PPC, ≥500 ng/ml | P | ||
| No. (%) | 16 (44) | 20 (56) | 4 (22) | 14 (78) | |||
| Mean (SD) age (yr) | 44.1 (17.6) | 52.5 (11.6) | 0.095 | 31 (7.3) | 44 (16.3) | 0.15 | 48.7 (15.0) |
| Mean (SD) BMI (kg/m2) | 21.6 (3.0) | 24.3 (4.2) | 0.055 | 15.8 (5.5) | 22.6 (4.0) | 0.07 | 23.2 (4.0) |
| No. (%) female | 7 (44) | 4 (20) | 0.16 | 1 (25) | 4 (28) | 1 | 16 (30) |
| Mean (SD) creatinine clearance (ml/min) | 89 (30) | 91 (25) | 0.92 | 116 (47.6) | 78 (45.0) | 0.16 | 89 (34) |
| Median (range) ALT level (IU/liter) before treatment | 29.5 (5-473) | 42.5 (6-151) | 0.35 | 38 (6-56) | 27 (13-59) | 1 | 35 (5-473) |
| No. (%) with: | |||||||
| Digestive disease | 10 (63) | 6 (30) | 0.051 | 3 (75) | 3 (21) | 0.083 | 22 (41) |
| Diarrhea | 10 (63) | 4 (20) | 0.0093 | 3 (75) | 1 (7) | 0.018 | 18 (33) |
| Mucositis | 6 (37.5) | 0 | 0.0041 | 0 | 0 | 6 (11) | |
| Allogeneic HSCT | 13 (81) | 14 (70) | 0.7 | 1 (25) | 4 (28) | 1 | 32 (59) |
| GVHD | 12 (75) | 13 (65) | 0.7 | 1 (25) | 3 (21) | 1 | 29 (54) |