TABLE 3.
Steady-state concentrations of voriconazole and anidulafungin in plasma, ELF, and AMs
| Time of BAL (h) | Concn (μg/ml)a |
|||||
|---|---|---|---|---|---|---|
| Voriconazole |
Anidulafungin |
|||||
| Plasma | ELF | AMs | Plasma | ELF | AMs | |
| 4 | 5.3 (1.4) | 48.3 (7.6) | 20.6 (4.5) | 6.0 (1.5) | 0.9 (0.1) | 44.6 (30.1) |
| 8 | 1.7 (0.9) | 10.1 (10.8) | 10.3 (8.5) | 5.1 (0.8) | 0.8 (0.4) | 37.9 (13.8) |
| 12 | 2.2 (1.1) | 17.2 (13.3) | 14.4 (13.1) | 4.4 (1.0) | 0.8 (0.2) | 42.7 (35.8) |
| 24 | NR | NR | NR | 3.0 (0.5) | 1.1 (0.4) | 103.1 (110.7) |
a
Data are presented as means (SDs); values are estimated on the basis of the results for five participants per time point. NR, not reported.