TABLE 2.
Susceptibility of PM-KO lines to CQ with or without VP
| Parasite line | IC50 (nM)a |
||
|---|---|---|---|
| CQ | m-dCQ | CQ + VP | |
| Dd2 | 194.4 ± 6.8 | 1,596 ± 81.4 | 79.4 ± 9.7 |
| Δpfpm1 | 177.4 ± 12.2 | 1,494 ± 87.9 | 55.8 ± 10.7 |
| Δpfpm2 | 175.0 ± 11.1 | 1,409 ± 28.6 | 59.9 ± 7.7 |
| Δpfpm3 | 145.0 ± 5.6** | 1,180 ± 116.3** | 47.4 ± 8.0 |
| Δpfpm4 | 144.2 ± 9.9** | 1,165 ± 142.5* | 63.0 ± 13.0 |
| GC03 | 23.9 ± 0.5*** | 29.6 ± 0.7*** | 19.5 ± 2.2*** |
| 3D7 | 22.6 ± 0.9 | 25.1 ± 0.7 | ND |
| Δ3pfpm | 17.0 ± 2.6 | 19.0 ± 2.9 | ND |
| Δ4pfpm | 24.7 ± 2.3 | 23.5 ± 0.6 | ND |
a
IC50s are expressed as means ± SEMs. Each value was determined from six to eight separate drug assays performed in duplicate. The degree of statistical significance is indicated with an asterisk(s): *, P < 0.05; **, P < 0.01; ***, P < 0.001. ND, not determined.