TABLE 2.
Pharmacokinetics of unbound cephalothin in patients with severe burns and in a healthy volunteer control group
| Patient | Cmax (mg/liter) | AUC0-∞ (mg/h/liter) | MRT (h) | t1/2 (h) | Vss (liters/kg) | CLT (liters/h/kg) | t1/2β (h) | CLCR (ml/min) | % Protein binding |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 30.5 | 13.36 | 0.95 | 0.66 | 0.81 | 0.85 | 1.25 | 163 | 65 |
| 2 | 32.9 | 7.00 | 0.39 | 0.27 | 0.79 | 2.04 | 0.81 | 202 | 63 |
| 3 | 24.6 | 12.76 | 0.73 | 0.51 | 0.72 | 0.98 | 0.86 | 169 | 46 |
| 4 | 35.9 | 15.72 | 1.07 | 0.74 | 0.85 | 0.80 | 1.17 | 81 | 62 |
| 5 | 32.1 | 6.92 | 0.30 | 0.21 | 0.48 | 1.61 | 0.76 | 170 | 72 |
| 6 | 21.8 | 10.05 | 0.58 | 0.40 | 0.64 | 1.11 | 0.91 | 64 | 65 |
| 7 | 65.9 | 14.63 | 0.45 | 0.31 | 0.44 | 0.98 | 0.95 | 125 | 58 |
| 8 | 23.6 | 7.00 | 0.35 | 0.24 | 0.50 | 1.43 | 0.66 | 307 | 51 |
| 9 | 80.9 | 21.01 | 0.53 | 0.37 | 0.46 | 0.87 | 0.82 | 52 | 52 |
| Mean (SD) for: | |||||||||
| Patients | 38.7 (19.4) | 12.05 (4.52) | 0.59 (0.25) | 0.41 (0.18) | 0.63 (0.16) | 1.19 (0.40) | 0.91 (0.18) | 148 (75) | 59 (8) |
| Volunteers (n = 5) | 21.3 (5.5) | 9.89 (2.83) | 0.38 (0.03) | 0.26 (0.02) | 0.60 (0.09) | 1.58 (0.15) | 0.74 (0.12) | 98 (19) | 71 (2) |