TABLE 2.
Effects of phosphonate negative charge on antischistosomal activities of (S)-HPMPA and two analogs
| Compound | Charge | EC50 (mM) | Max. % worm mortality |
|---|---|---|---|
| (S)-HPMPA | −2 | >100 | 13.3 |
| HDP-(S)-HPMPA | −1 | >100 | 30.8 |
| HDP-cyclic-(S)-HPMPA | 0 | 5.0 | 93.3 |
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