FIG. 2.

Serial passage of MSSA 29213 and MRSA 33591 in the presence of TR-700 and LZD. Total mutant population MICs are plotted for each serial passage of ATCC 29213 and ATCC 33591 with TR-700 and LZD. Underlying mutations in 23S rRNA genes and ribosomal proteins L3 and L4 are shown corresponding to the stepwise MICs at which they were identified by analysis of individual colonies. Fractional 23S rRNA values indicate the number of mutant alleles out of the total number of 23S alleles detected by PCR.