TABLE 3.
Pharmacokinetic parameters of AHM following single ascending i.v. infusions
| AHM dose (mg)a | AUC0- last (mg·h·liter−1) | AUC0-∞ (mg·h·liter−1) | Cmax (μg·liter−1) | Tmax (h) | t1/2 (h) | CL (liter·h−1) | V (liters) | Dose-normalizedb: |
||
|---|---|---|---|---|---|---|---|---|---|---|
| AUC0-last | AUC0-∞ | Cmax | ||||||||
| 5 | 78.4 ± 22.3 | 70.5 ± 12.6 | 517 ± 23.8 | 0.50 ± 0.00 | 112 ± 42.0 | 0.069 ± 0.021 | 10.1 ± 1.22 | 14.1 ± 3.25 | 15.7 ± 4.47 | 103 ± 4.78 |
| 10 | 92.0 ± 33.0 | 101.6 ± 38.8 | 796 ± 66.5 | 0.50 ± 0.00 | 91.7 ± 34.9 | 0.12 ± 0.054 | 13.1 ± 2.71 | 9.20 ± 3.30 | 10.2 ± 3.88 | 79.6 ± 6.65 |
| 20 | 236 ± 29.8 | 263 ± 40.3 | 1,487 ± 91.0 | 0.50 ± 0.00 | 124 ± 21.9 | 0.078 ± 0.014 | 13.6 ± 1.61 | 11.8 ± 1.49 | 13.2 ± 2.02 | 74.3 ± 4.55 |
a
Values are means±standard deviations (n = 10 for each dose).
b
Regression analysis of dose-normalized parameters revealed no statistically significant difference across the dosage levels.