Decline in linkage around the pfdhfr gene (x axis denotes the distance of the microsatellite marker from the pfdhfr gene [in kb], whereas the y axis denotes the value of EHH at that locus). □, A16N51C59S108I164; ▵, A16N51C59N108I164; ⋄, A16N51R59N108I164; ○, A16I51R59N108I164/A16N51R59N108L164; *, A16I51R59N108L164.