TABLE 1.
AUC24/MIC ratios required for 24-h bacteriostatic effect and 1-, 2-, and 3-log reductions in bacterial count
| Strain or analysis | MIC (mg/liter) | AUC24/MIC required for: |
|||
|---|---|---|---|---|---|
| 24-h bacteriostatic effect | 1-log drop | 2-log drop | 3-log drop | ||
| Strain | |||||
| 36633 | 0.03 | 53.7 | 61.7 | 70.8 | 83.2 |
| 37099 | 0.03 | 41.7 | 49.0 | 56.2 | 67.6 |
| 37312 | 0.03 | 18.6 | 22.4 | 26.3 | 30.9 |
| 37390 | 0.04 | 12.0 | 15.1 | 18.6 | 25.1 |
| 37503 | 0.05 | 20.4 | 30.2 | 45.7 | 85.1 |
| 38002 | 0.05 | 16.6 | 19.1 | 21.4 | 25.1 |
| 38004 | 0.09 | 8.7 | 19.5 | 41.7 | 95.5 |
| 37276 | 0.7 | 30.2 | 43.7 | 64.6 | 120.0 |
| 36742 | 1 | 19.5 | 20.9 | 23.4 | 25.4 |
| 36945 | 2 | 42.7 | 52.7 | 89.1 | |
| Mean ± SD | 26.4 ± 15.0 | 33.4 ± 16.8 | 45.8 ± 24.0 | 62.0 ± 36.3 | |
| Pooled single-point analysis | 18.6 | 26.9 | 38.9 | 69.2 | |