TABLE 2.

Percentage of patients achieving target AUC₂₄/MICs

Estimation	MIC (mg/liter)	% of patients with target AUC24/MICs (log10 drop in CFU/ml at 24 h)
		0	−1	−2	−3
Empirical estimation of the distribution of targets	0.06	100	100	100	89.7
	0.12	100	100	99.9	88.8
	0.25	99.4	98.4	89.4	61.4
	0.5	80.6	68.1	49.5	38.0
	1.0	46.8	31.2	16.4	7.5
	2.0	10.2	0.8	0.2	0
Normal-based estimation of distribution of targets	0.06	100	100	100	100
	0.12	100	100	99.9	98.6
	0.25	99.4	98.3	89.6	71.6
	0.5	81.6	68.5	45.5	30.6
	1.0	36.9	25.3	16.0	13.8
	2.0	15.0	9.1	7.3	8.2
Single-point estimation of target using pooled data for all strains	0.06	100	100	100	100
	0.12	100	100	100	100
	0.25	100	100	99.6	77.1
	0.5	99.8	95.5	61.8	1.8
	1.0	68.0	16.0	0.8	0
	2.0	1.1	0	0	0