FIG. 3.

TLR2 is not activated by Veillonella LPS. Peritoneal macrophages from wild-type and TLR2 gene-deficient mice were stimulated with Veillonella LPS for 24 h. As a control, cells were stimulated with Pam₃Cys (a potent TLR2 ligand). (A) Murine TNF-α and IL-10 production induced by Veillonella LPS. (B) Murine IL-1α and IL-6 levels. Note that Pam₃Cys-induced cytokine production was abrogated in TLR2 knockout (TLR2ko) cells. Data represent the means ± standard deviations for cytokine production by at least five mice. *, P < 0.01 (Wilcoxon rank test).