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. 2009 Oct 5;77(12):5300–5310. doi: 10.1128/IAI.00501-09

FIG. 8.

FIG. 8.

Survival curves of MyD88 −/− mice after i.n. administration of live or paraformaldehyde (PAF)-killed E. coli strain HB101 followed by challenge with 38 CFU of P. aeruginosa strain PAO1 or 256 CFU of strain PA14 i.n. The RB6, live HB101 group was given MAb RB6-8C5, 0.200 mg i.p., once on day zero, E. coli strain HB101 i.n. on day 1 (24 h); or 38 CFU of PAO1 i.n. on day 2 (48 h). Median survival of mice given live HB101 and subsequent i.n. P. aeruginosa was higher than that of mice treated with PAF-HB101 (P = 0.0012 for PAO1 group, log rank test). Each group contained eight mice. Values in parentheses indicate the average P. aeruginosa inoculum CFU.