FIG. 1.

Greater numbers of memory CD4⁺ and CD8⁺ T-cell populations are maintained in the spleen in the presence of persistent E. muris. Significantly greater frequencies (P < 0.05) of effector/effector memory CD4⁺ and CD8⁺ T cells were present in the spleens of E. muris-primed mice treated with doxycycline and in mice persistently infected with E. muris on day 36 after primary infection compared to naive mice. The data are representative of three independent experiments with three mice per group.