FIG. 3.

i.n. challenge of BALB/c mice with Burkholderia. Groups of six BALB/c mice were infected i.n. with increasing doses (CFU) of DD503 (A), JW270 (B), or E264 (C). For 14 days, mice were monitored at 8-h intervals for indications of terminal infection, and animals were euthanized prior to death. GraphPad Prism 5 was used for data presentation and statistical analysis. Asterisks indicate significant differences between the JW270 and E264 survival curves and the survival curves for the same doses of DD503 as determined using the log rank (Mantel-Cox) test (*, P < 0.05; **, P < 0.01; ***, P < 0.001).