FIG. 5.

Effects of caspase inhibitors on TcdA- and TRAIL-induced cell death in colonic cells. (A) T84 and caco-2 cells were treated with increasing concentrations of TRAIL for 48 h. Cell viability was assessed by XTT assay. (B) T84 and caco-2 cells were incubated with various caspase inhibitors (casp inh) (all at 10 μM) for 1 h and then treated with TcdA (0.5 ng/ml) for 48 h. Cell viability was assessed by XTT assay. The data are means ± SEM of three independent experiments performed in triplicate.