TABLE 3.
Virulence of S. enterica serovar Typhimurium in the mouse infection modela
| Strain or control | No. of mice (n = 6) that reached the clinical end point challenged with the following doseb: |
||
|---|---|---|---|
| 105 CFU | 106 CFU | 107 CFU | |
| SL1344 | 5 | 6 | 6 |
| SL1344LS | 6 | 5 | 6 |
| PBS (control) | 0 | 0 | 0 |
a
Female BALB/c mice were challenged orally with 105, 106, or 107 CFU. of S. Typhimurium SL1344 (wild type), the isogenic luxS mutant SL1344LS, or sterile PBS as a control.
b
The number of mice that reached the clinical end point at 12 days postchallenge is shown. Mice that reached the clinical end point, i.e., the point of infection where severe symptoms appeared to be due to high bacterial burdens, were removed from the group. In the control group, all mice remained well when inoculated with PBS.