TABLE 1.

Classification, localization, and function of Saccharomyces cerevisiae ABC transporters^a

Family	Transporter	ORF	Localization	Description	Reference(s)
ABCB	MDL1	YLR188w	Mitochondrial inner membrane	Involved in export of peptides from mitochondria, plays a role regulating oxidative stress; function may overlap with that of ATM1; homodimerizes	20, 172
	MDL2	YPL279w	Mitochondrial inner membrane	Unknown; homodimerizes	96
	ATM1	YMR301c	Mitochondrial inner membrane	Essential for cytosolic iron-sulfur clusters and iron homeostasis; homodimerizes	80
	STE6	YKL209c	Plasma membrane	Exporter of a-factor pheromone in MATa cells	79, 106
ABCC	VMR1	YHL035c	Vacuole	Unknown	30
	YBT1	YLL048c	Vacuole	Transports bile acid in vitro; transports Ade2 pigment in vivo	113, 144
	NFT1	YKR103/104	Vacuole	Unknown	102
	YCF1	YDR135c	Vacuole	Glutathione S-conjugate transporter involved in cellular detoxification; transports heavy metals such as cadmium, mercury, lead, and arsenite; transports Ade2 pigment; bile pigments and MRI contrast agents are in vitro substrates and unconjugated bilirubin	94, 120, 154
	BPT1	YLL015w	Vacuole	Glutathione S-conjugate transporter involved in cellular detoxification; transports cadmium and Ade2 pigment in vivo; function overlaps with that of Ycf1p	83, 120
	YOR1	YGR281c	Plasma membrane	Multidrug transporter; exports oligomycin, organic anions, and many other compounds	23, 76
ABCD	PXA1	YPL147w	Peroxisome	Implicated in transport of acyl coenzyme A esters across the peroxisomal membrane; heterodimerizes with Pxa2p	60, 142, 143
	PXA2	YKL188c	Peroxisome	Implicated in transport of acyl coenzyme A esters across the peroxisomal membrane; heterodimerizes with Pxa1p	60, 142, 143
ABCG	PDR5	YOR153w	Plasma membrane	Multidrug transporter involved in resistance to xenobiotic compounds (mutagens and anticancer drugs) and cations and in steroid transport	7, 100, 109
	PDR15	YDR406w	Plasma membrane	Multidrug transporter involved in general stress response for cellular detoxification	168, 169
	PDR10	YOR328w	Plasma membrane	Multidrug transporter involved in the pleiotropic drug resistance network	6, 168
	SNQ2	YDR011w	Plasma membrane	Multidrug transporter involved in multidrug resistance and resistance to singlet-oxygen species	141, 161
	PDR18	YNR070w	Plasma membrane	Putative transporter implicated in pleiotropic drug resistance	9, 132
	PDR12	YPL058c	Plasma membrane	Multidrug transporter involved in weak organic acid resistance	65, 121
	PDR11	YIL013c	Plasma membrane	Multidrug transporter involved in multidrug resistance and mediating sterol uptake	134, 167
	AUS1	YOR011w	Plasma membrane	Involved in sterol uptake	167
	YOL075c	YOL075c	Plasma membrane	Unknown	30
	ADP1	YCR011c	Plasma membrane	Unknown	30

^aThe ABC transporters are listed by formal name and ORF name and are grouped into their respective subfamilies as described in the text and in the legends of Fig. 2 and 4.