TABLE 2.

Distribution of Ask cohesion groups in the phylum Firmicutes

Cohesion group	Functional specialization	No. of members	Subhomology division	Internal start site present	Allosterya	Gene contextb	Phylogenetic breadth of distribution
CG-03	Threonine	37	ASKα	No	Lysine-threonine synergism	thr+met; thr; lys or null	Phylum: Firmicutes
CG-24	DAP	27	ASKβ	No	Diaminopimelate	dap	Phylum: Firmicutes
CG-28	Lysine	2	ASKβ	Yes	Lysine (Fig. 10)	lys	Genus: Clostridium
CG-30	Lysine	4	ASKβ	Yes	Lysine (Fig. 10)	lys	Genus: Staphylococcus
CG-33	Lysine	9	ASKβ	Yes	Lysine		Family: Bacillaceae; Listeriaceae
CG-45	Threonine	3	ASKβ	Yes	Threonine (Fig. 10)	thr+met	Order: Clostridiales
Orphan	Threonine	1	ASKβ	Yes	Threonine (Fig. 10)	thr+met	Syntrophomonas wolfei
Orphan	Threonine	1	ASKβ	Yes	Threonine (Fig. 10)	met; SAM riboswitch	Symbiobacterium thermophilum
Orphan	Threonine	1	ASKβ	Yes	Threonine (Fig. 10)	thr+met	Carboxydothermus hydrogenoformans
Orphan	Threonine	1	ASKβ	Yes	Threonine (Fig. 10)	thr+met	Moorella thermoacetica

^aThe indicated pattern of allostery is known to typify some members of CG-03, but is not necessarily present in all members.

^bThe indicated context is not always present with respect to every cohesion group member.