TABLE 3.
Associations between other putative virulence genes of MRSA isolates and clinical outcome
| Category and gene | No. (%) of MRSA patients (n = 522) | No. of cured patients/total no. of patients (%) with indicated gene status |
Pa | |
|---|---|---|---|---|
| Absent | Present | |||
| Adhesins | ||||
| fnbA | 471 (90.2) | 39/51 (76.5) | 433/471 (91.9) | 0.015 |
| clfA | 521 (99.8) | 1/1 (100.0) | 471/521 (90.4) | 1.000 |
| clfB | 494 (94.6) | 22/28 (78.6) | 450/494 (91.1) | 0.107 |
| cna | 34 (6.5) | 446/488 (91.4) | 26/34 (76.5) | 0.036 |
| spa | 522 (100.0) | 0/0 | 472/522 (90.4) | 1.000 |
| sdrC | 503 (96.4) | 13/19 (68.4) | 459/503 (91.3) | 0.026 |
| sdrD | 502 (96.2) | 18/20 (90.0) | 454/502 (90.4) | 1.000 |
| sdrE | 508 (97.3) | 11/14 (78.6) | 461/508 (90.7) | 0.258 |
| bbp | 516 (98.9) | 5/6 (83.3) | 467/516 (90.5) | 0.705 |
| ebpS | 522 (100.0) | 0/0 | 472/522 (90.4) | 1.000 |
| map-eap | 455 (87.2) | 53/67 (79.1) | 419/455 (92.1) | 0.016 |
| fnbB | 497 (95.2) | 20/25 (80.0) | 452/497 (90.9) | 0.191 |
| Toxins | ||||
| eta | 91 (17.4) | 394/431 (91.4) | 78/91 (85.7) | 0.254 |
| etb | 1 (0.2) | 471/521 (90.4) | 1/1 (100.0) | 1.000 |
| tst | 166 (31.8) | 323/356 (90.7) | 149/166 (89.8) | 1.000 |
| sea | 51 (9.8) | 429/471 (91.1) | 43/51 (84.3) | 0.258 |
| seb | 3 (0.6) | 469/519 (90.4) | 3/3 (100.0) | 1.000 |
| sec | 11 (2.1) | 462/511 (90.4) | 10/11 (90.9) | 1.000 |
| sed | 27 (5.2) | 452/495 (91.3) | 20/27 (74.1) | 0.036 |
| see | 8 (1.5) | 466/514 (90.7) | 6/8 (75.0) | 0.299 |
| seg | 55 (10.5) | 429/467 (91.9) | 43/55 (78.2) | 0.016 |
| seh | 7 (1.3) | 467/515 (90.7) | 5/7 (71.4) | 0.258 |
| sei | 64 (12.3) | 422/458 (92.1) | 50/64 (78.1) | 0.015 |
| sej | 24 (4.6) | 456/498 (91.6) | 16/24 (66.7) | 0.015 |
| hlg | 521 (99.8) | 1/1 (100.0) | 471/521 (90.4) | 1.000 |
| Others | ||||
| efb | 520 (99.6) | 2/2 (100.0) | 470/520 (90.4) | 1.000 |
| icaA | 506 (96.9) | 15/16 (93.8) | 457/506 (90.3) | 1.000 |
| chp | 483 (92.5) | 33/39 (84.6) | 439/483 (90.9) | 0.408 |
| V8 | 514 (98.5) | 5/8 (62.5) | 467/514 (90.9) | 0.093 |
| SCCmec type IV | 466 (89.3) | 45/56 (80.4) | 427/466 (91.6) | 0.042 |
| agr group II vs all others | 40 (7.7) | 442/482 (91.7) | 30/40 (75.0) | 0.016 |
a
P values are adjusted for multiple comparisons to control the false-discovery rate for the family of all tests within this table to 20%.