TABLE 3.
Analysis of most recent common ancestor in each cluster
| Cluster | Genotype | No. of sequences | Yr of origin (95% CI) | No. (%)b of lineage splits since: |
||
|---|---|---|---|---|---|---|
| 1980 | 1990 | 2000 | ||||
| C1a | 4a | 43 | 1881 (1833-1912) | 3 (7) | 1 (2) | 1 (2) |
| C2 | 4d | 44 | 1954 (1936-1965) | 12 (28) | 4 (9) | 1 (2) |
| C2, excluding patients 7, 28, 55, 69, and 81 | 4d | 39 | 1966 (1952-1974) | 12 (32) | 4 (11) | 1 (3) |
| C3a | 4d | 22 | 1985 (1977-1989) | 21 (100) | 19 (90) | 12 (57) |
| C3a | 4d | 12 | 1992 (1988-1995) | 11 (100) | 11 (100) | 9 (82) |
| C3b | 4d | 5 | 1994 (1989-1997) | 4 (100) | 4 (100) | 0 (0) |
| C3c | 4d | 5 | 1997 (1994-1999) | 4 (100) | 4 (100) | 3 (75) |
a
Calculations were based on data for patients for whom both PCR fragments were available. For C1, three patients lacked NS5B fragment 1; for C3, four patients lacked NS5B fragment 1.
b
The number of possible lineage splits per cluster (100%) is equivalent to the number of sequences in that cluster minus 1.