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In vitro replication in bone marrow derived macrophages. Primary BMM were infected with WT HSV-1 at an MOI of 1 or 0.01. At the indicated times postinfection, cells and supernatants were harvested, and virus titers were assayed on Vero cells. The results shown are mean titers of four independent experiments. *, P < 0.05; **, P < 0.01; ***, P < 0.001.
