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Kinetics of viral replication in vivo. Groups of 6-week-old female BALB/c mice were mock infected or infected with HSV-1(F), R3616, or H9813 via bilateral corneal scarification with 4 × 105 PFU of virus. Mice from each group were sacrificed on days 1, 3, 5, and 7. At this time, tissue samples from the eye (A), trigeminal ganglia (TG) (B), or brain stem (BS) (C) were used for titration on Vero cells. Data are expressed as means ± standard deviations for five mice for each group.
