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. 2009 Nov 16;119(12):3613–3625. doi: 10.1172/JCI38988

Figure 8. FAP regulates accumulation of collagen in vivo.

Figure 8

(A) Sections of CT26 tumors were stained with Picro-Sirius red and visualized under polarized light (top row) and bright field (bottom row). The increase in orange birefringence in tumors from FapLacZ/LacZ mice reflects less organized collagen. Original magnification, ×20. Scale bar: 100 μm. (B) Collagen content of CT26 tumors (100 mm2) from Fap+/+ and FapLacZ/LacZ mice. Data represent mean ± SEM of 20 tumors per genotype. (C) Collagen content of lungs from uninfected (n = 3) mice and LSL–K-rasG12D;Fap+/+ (n = 6), LSL–K-rasG12D;Fap+/LacZ (n = 6), and LSL–K-rasG12D;FapLacZ/LacZ mice (n = 6) 8 weeks after Ad-Cre infection. Results are expressed as mean ± SEM.