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. 2009 Nov 9;119(12):3692–3702. doi: 10.1172/JCI39716

Figure 5. Quantification of inhibition of neuronal CCEs in prevention trial of NSAIDs.

Figure 5

Percentages of NeuN-positive neurons in cortical layers II/III exhibiting expression of cyclin A (A) or cyclin D (B) as well as 3 or 4 spots of hybridization with FISH for DNA probes from mouse chromosome 16 (C) and 13 (D) was calculated in R1.40 transgenic mice fed control, ibuprofen-containing, and naproxen-containing diets as well as in nontransgenic mice fed the control diet (n = 5). **P < 0.003, ***P < 0.001 versus control diet–fed R1.40 transgenic mice.