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. 2009 Nov 16;119(12):3807–3816. doi: 10.1172/JCI39738

Figure 6. JNK activation following hypoxia-reoxygenation according to MIF promoter genotype in human fibroblasts.

Figure 6

Dermal fibroblasts from subjects with the MIF promoter low-expression 5-CATT repeat allele (5/5 genotype; n = 5) and subjects with at least 1 high expression 6- or 7-CATT repeat allele (non-5/5 genotype; n = 7) were subjected to normoxic control incubation or 9 hours of hypoxia and 30 minutes of reoxygenation (hypoxia-reO2). Lysates were immunoblotted with phospho-specific and total JNK (A) and c-Jun (B) antibodies. Quantification of immunoblots is shown in the graphs below the blots. *P < 0.05 versus control; #P < 0.05 versus 5/5 hypoxia-reoxygenation.